The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.

@article{Koong1994TheRO,
  title={The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors.},
  author={Albert C. Koong and Elizabeth A. Auger and Eunice Y Chen and Amato J. Giaccia},
  journal={Radiation research},
  year={1994},
  volume={138 1 Suppl},
  pages={S60-3}
}
In this study, we have shown that steady-state levels of glucose-regulated 78 kDa (GRP78) protein and messenger RNA increase during a 5-h exposure to 0.02% oxygen. This increase in GRP78 protein and mRNA induced by hypoxia can be abolished by a 1-h pretreatment of cells before hypoxia with the protein kinase C (PKC) inhibitors staurosporine and H7 at concentrations at which the drugs themselves do not cause cytotoxicity. Although all studies using protein kinase inhibitors must be interpreted… CONTINUE READING