The regulation of EN-RAGE (S100A12) gene expression in human THP-1 macrophages.

@article{Hasegawa2003TheRO,
  title={The regulation of EN-RAGE (S100A12) gene expression in human THP-1 macrophages.},
  author={Takamasa Hasegawa and Atsushi Kosaki and Tatsuji Kimura and Hiroaki Matsubara and Yasukiyo Mori and Mitsuhiko Okigaki and Hiroya Masaki and Nagaoki Toyoda and Megumi Inoue-Shibata and Yutaka Kimura and Mitsushige Nishikawa and Toshiji Iwasaka},
  journal={Atherosclerosis},
  year={2003},
  volume={171 2},
  pages={211-8}
}
EN-RAGE is a ligand for the receptor for advanced glycation end products (RAGE) and may be involved in the development of diabetic macro- and micro-angiopathy. This study is designed to investigate the regulation of EN-RAGE gene expression in human macrophages. The amounts of EN-RAGE mRNA were measured in cultured human THP-1 macrophages after treatment with various stimuli known to modulate atherosclerosis. First, interleukin-6 (IL-6), a proinflammatory cytokine, increased the level of EN-RAGE… CONTINUE READING