The regulation of 6-phosphofructo-1-kinase by insulin and glucagon in isolated hepatocytes of the American eel.

@article{Foster1989TheRO,
  title={The regulation of 6-phosphofructo-1-kinase by insulin and glucagon in isolated hepatocytes of the American eel.},
  author={Glen D. Foster and Kenneth B. Storey and Thomas Moon},
  journal={General and comparative endocrinology},
  year={1989},
  volume={73 3},
  pages={382-9}
}
Kinetic characteristics of American eel liver 6-phosphofructo-1-kinase (PFK-1) and the effects of porcine insulin, bovine glucagon, and dibutyryl-cAMP were studied. At 0.1 mM ATP, kinetics were sigmoidal with respect to fructose-6-phosphate (F-6-P) concentrations and the S0.5 (F-6-P) increased with higher ATP concentrations. At 2 mM F-6-P, optimal ATP concentrations were 0.1 mM, with maximal inhibition at 0.5 mM. Fructose 2,6-bisphosphate (Fru-2,6-P2) offset ATP inhibition and activated the… CONTINUE READING

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