The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea.

@article{Hourvitz2002TheRE,
  title={The regulated expression of the pregnancy-associated plasma protein-A in the rodent ovary: a proposed role in the development of dominant follicles and of corpora lutea.},
  author={Ariel Hourvitz and Akira Kuwahara and Jon D. Hennebold and Adriano Bueno Tavares and Hiroaki Negishi and Taek Hoo Lee and Gregory F. Erickson and Eli Y Adashi},
  journal={Endocrinology},
  year={2002},
  volume={143 5},
  pages={
          1833-44
        }
}
Compelling evidence exists displaying that the intrafollicular IGF-I system constitutes an obligatory mediator of FSH action in the murine ovary. Within this system, the ovarian IGF binding protein-4-directed protease (IGFBP-4ase) may have a critical role. Human IGFBP-4ase has been proved identical to the previously well-characterized pregnancy-associated plasma protein-A (PAPP-A). This communication reports the cloning and sequencing of the mouse PAPP-A cDNA as well as its expression and… CONTINUE READING
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