The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded.

@article{Cox2002TheRO,
  title={The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded.},
  author={Cathleen J Cox and Kaushik Dutta and Edward T Petri and William C. Hwang and Yaqiong Lin and Steven M Pascal and Ravi Basavappa},
  journal={FEBS letters},
  year={2002},
  volume={527 1-3},
  pages={303-8}
}
The proteins securin and cyclin B are destroyed in mitosis by the ubiquitin/proteasome system. This destruction is important to mitotic progression. The N-terminal regions of these proteins contain the sequence features recognized by the ubiquitination system. We have demonstrated using circular dichroism and 1-D and 2-D nuclear magnetic resonance that these rather substantial regions are natively unfolded. Based on these findings, we propose a model that helps to explain previously enigmatic… CONTINUE READING

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