The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.

@article{Hardwicke1989TheRI,
  title={The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.},
  author={M A Hardwicke and Paula J. Vaughan and Rose E. Sekulovich and Robert E O'Conner and Rozanne M Sandri-Goldin},
  journal={Journal of virology},
  year={1989},
  volume={63 11},
  pages={4590-602}
}
The herpes simplex virus type 1 (HSV-1) alpha or immediate-early proteins ICP4 (IE175), ICP0 (IE110), and ICP27 (IE63) are trans-acting proteins which affect HSV-1 gene expression. We previously showed that ICP27 in combination with ICP4 and ICP0 could act as a repressor or an activator in transfection assays, depending on the target gene (R. E. Sekulovich, K. Leary, and R. M. Sandri-Goldin, J. Virol. 62:4510-4522, 1988). To investigate the regions of the ICP27 protein which specify these… CONTINUE READING
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