The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals

@article{Hore2007TheRH,
  title={The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals},
  author={Timothy Alexander Hore and Edda Koina and Matthew J. Wakefield and Jennifer A. Marshall Graves},
  journal={Chromosome Research},
  year={2007},
  volume={15},
  pages={147-161}
}
Marsupial, as well as eutherian, mammals are subject to X chromosome inactivation in the somatic cells of females, although the phenotype and the molecular mechanism differ in important respects. Monotreme mammals appear to subscribe at least to a form of dosage compensation of X-borne genes. An important question is whether inactivation in these non-eutherian mammals involves co-ordination by a control locus homologous to the XIST gene and neighbouring genes, which play a key regulatory role… CONTINUE READING

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