The regenerative potential of parietal epithelial cells in adult mice.

@article{Berger2014TheRP,
  title={The regenerative potential of parietal epithelial cells in adult mice.},
  author={Katja Berger and Kevin Schulte and Peter Boor and Christoph Kuppe and Toin H van Kuppevelt and Juergen Floege and Bart Smeets and Marcus M{\"o}ller},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2014},
  volume={25 4},
  pages={693-705}
}
Previously, we showed that some podocytes in juvenile mice are recruited from cells lining Bowman's capsule, suggesting that parietal epithelial cells (PECs) are a progenitor cell population for podocytes. To investigate whether PECs also replenish podocytes in adult mice, PECs were genetically labeled in an irreversible fashion in 5-week-old mice. No significant increase in labeled podocytes was observed, even after 18 months. To accelerate a potential regenerative mechanism, progressive… CONTINUE READING