The refined crystal structure of subtilisin Carlsberg at 2.5 A resolution.

@article{Neidhart1988TheRC,
  title={The refined crystal structure of subtilisin Carlsberg at 2.5 A resolution.},
  author={David J. Neidhart and Gregory A. Petsko},
  journal={Protein engineering},
  year={1988},
  volume={2 4},
  pages={271-6}
}
We report here the X-ray crystal structure of native subtilisin Carlsberg, solved at 2.5 A resolution by molecular replacement and refined by restrained least squares to a crystallographic residual (Formula see text): of 0.206. we compare this structure to the crystal structure of subtilisin BPN'. We find that, despite 82 amino acid substitutions and one deletion in subtilisin Carlsberg relative to subtilisin BPN', the structures of these enzymes are remarkably similar. We calculate an r.m.s… CONTINUE READING

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