The reelin signaling pathway: some recent developments.

  title={The reelin signaling pathway: some recent developments.},
  author={Yves Jossin and Isabelle Bar and Nina Ignatova and Fadel Tissir and Catherine Lambert de Rouvroit and Andre M Goffinet},
  journal={Cerebral cortex},
  volume={13 6},
The Reelin signaling pathway plays a key role in the architectonic development of the central nervous system. Extracellular Reelin binds to receptors of the lipoprotein receptor family and induces tyrosine phosphorylation of the adaptor Dab1. In this paper, we discuss three recent developments. First, we show that the central part of Reelin is involved in receptor binding and signal activation as reflected in Dab1 phosphorylation. Second, we examine the genomic organization, alternative… CONTINUE READING


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