The reduction of glutathione disulfide produced by t-butyl hydroperoxide in respiring mitochondria.

@article{Liu1996TheRO,
  title={The reduction of glutathione disulfide produced by t-butyl hydroperoxide in respiring mitochondria.},
  author={Hui Liu and James P. Kehrer},
  journal={Free radical biology & medicine},
  year={1996},
  volume={20 3},
  pages={
          433-42
        }
}
Factors affecting the reduction of GSSG by rat liver mitochondria after a t-butyl hydroperoxide-induced (t-BOOH) oxidative stress were studied. The amounts of ADP and mitochondrial protein were adjusted to consume less than 50% of the available oxygen during the 8-min experimental period. A 4-min treatment of mitochondria with 24 nmol t-BOOH/mg protein (60 microM) oxidized 91% of total glutathione. In the presence of glutamate/malate, succinate or ascorbate/N,N,N',N'-tetramethyl-p… CONTINUE READING

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