The redox state of glutathione regulates the hypoxic induction of HIF-1.

  title={The redox state of glutathione regulates the hypoxic induction of HIF-1.},
  author={Masamichi Tajima and Yukiko Kurashima and Kenji Sugiyama and Tsutomu Ogura and Hiroshi Sakagami},
  journal={European journal of pharmacology},
  volume={606 1-3},
Hypoxia inducible factor 1 (HIF-1) regulates the transcription of vascular endothelial growth factor (VEGF), which plays important roles in angiogenesis. We investigated the redox effect of glutathione (GSH) on the hypoxic induction of HIF-1 in a human oral squamous cell carcinoma (HSC-2) cell line. The maximal induction of HIF-1 in HSC-2 cells was observed 30 h after hypoxia, and VEGF mRNA was expressed after 36 h under hypoxia. GSH ethyl ester (GSHee, a membrane permeable analog of GSH) and N… CONTINUE READING


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