Corpus ID: 26223257

The redox chemistry of the Alzheimer's disease amyloid beta peptide.

  title={The redox chemistry of the Alzheimer's disease amyloid beta peptide.},
  author={D. Smith and R. Cappai and K. Barnham},
  journal={Biochimica et biophysica acta},
  volume={1768 8},
  • D. Smith, R. Cappai, K. Barnham
  • Published 2007
  • Medicine
  • Biochimica et biophysica acta
  • There is a growing body of evidence to support a role for oxidative stress in Alzheimer's disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation products (HNE, 8-HO-guanidine and protein carbonyls respectively) in AD brains. The brain is a highly oxidative organ consuming 20% of the body's oxygen despite accounting for only 2% of the total body weight. With normal ageing the brain accumulates metals ions such iron (Fe), zinc (Zn) and copper (Cu). Consequently the… CONTINUE READING
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