The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

@article{Xanthoudakis1996TheRR,
  title={The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.},
  author={Steve Xanthoudakis and Richard J Smeyne and Jennifer D Wallace and Tom Curran},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 17},
  pages={8919-23}
}
The DNA-binding activity of AP-1 proteins is modulated, in vitro, by a posttranslational mechanism involving reduction oxidation. This mode of regulation has been proposed to control both the transcriptional activity and the oncogenic potential of Fos and Jun. Previous studies revealed that reduction of oxidized Fos and Jun by a cellular protein, Ref-1, stimulates sequence-specific AP-1 DNA-binding activity. Ref-1, a bifunctional protein, is also capable of initiating the repair of apurinic… CONTINUE READING
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