The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)

In the past HepG2 cells have been considered to show only little similarity to primary human hepatocytes (Godoy et al., 2013; Hewitt et al., 2007). However, recently it has become clear that the phenotype of HepG2 cells strongly depends on culture conditions. In a recent study, Ramaiahgari et al. (2014) cultivated HepG2 cells in spheroids. In this culture… CONTINUE READING