The red blood cell as an oxygen sensor: what is the evidence?

@article{Ellsworth2000TheRB,
  title={The red blood cell as an oxygen sensor: what is the evidence?},
  author={Mary L. Ellsworth},
  journal={Acta physiologica Scandinavica},
  year={2000},
  volume={168 4},
  pages={551-9}
}
The matching of oxygen supply with demand requires the existence of a mechanism within the tissue capable of both sensing tissue oxygen need and inducing alterations in vascular perfusion necessary to meet that need. Historically, localized sites within the tissue and the vessels themselves have been investigated with the sensor site failing to be determined. Within the last decade, studies have focused on the red blood cell, the efficient carrier of oxygen, as a possible candidate. The red… CONTINUE READING

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