The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

@inproceedings{Tzaban2009TheRA,
  title={The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity},
  author={Salit Tzaban and Ramiro H. Massol and Elizabeth Yen and Wendy Hamman and Scott R. Frank and Lynne A. Lapierre and Steen H Hansen and James R Goldenring and Richard S Blumberg and Wayne I Lencer},
  booktitle={The Journal of cell biology},
  year={2009}
}
The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense. We show that FcRn traffics IgG from either apical or basolateral membranes into the recycling endosome (RE), after which the actin motor myosin Vb and the GTPase Rab25 regulate a sorting step that specifies transcytosis without affecting recycling. Another regulatory component of the RE, Rab11a, is dispensable for transcytosis, but… CONTINUE READING