The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma.

@article{Fonseca2003TheRI,
  title={The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma.},
  author={Rafael Fonseca and Carina S Debes-Marun and Elisa B Picken and Gordon W. Dewald and Sandra C Bryant and J Mitchell Winkler and Emily A. Blood and Martin M. Oken and Rafael Santana-Davila and Natalia C Gonzalez-Paz and Robert A Kyle and Morie A Gertz and Angela Dispenzieri and Martha Q. Lacy and Philip R. Greipp},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2562-7}
}
Aneuploid is ubiquitous in multiple myeloma (MM), and 4 cytogenetic subcategories are recognized: hypodiploid (associated with a shorter survival), pseudodiploid, hyperdiploid, and near-tetraploid MM. The hypodiploid, pseudodiploid, and near-tetraploid karyotypes can be referred to as the nonhyperdiploid MM. Immunoglobulin heavy-chain (IgH) translocations are seen in 60% of patients. We studied the relation between aneuploidy and IgH translocations in MM. Eighty patients with MM and abnormal… CONTINUE READING