The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model.

@article{Tasso2010TheRO,
  title={The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model.},
  author={Roberta Tasso and Franco Fais and Daniele Reverberi and Federico Tortelli and Ranieri Cancedda},
  journal={Biomaterials},
  year={2010},
  volume={31 8},
  pages={
          2121-9
        }
}
Angiogenesis plays a central role in bone regeneration, not only for the transport of nutrients, but also for locally directing skeletal stem/progenitor cells. Following ectopic implantation of porous ceramic cubes seeded with mouse GFP-labeled mesenchymal stem cells (MSC) into syngenic mice, we investigated the cascade of events leading to bone formation. Implants harvested at different times were enzymatically digested to generate single-cell suspensions. Recovered cells were sorted to… CONTINUE READING

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