The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes.

@article{Rocca2012TheRO,
  title={The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes.},
  author={Bianca Rocca and Francesca Santilli and Dario Pitocco and Luciana Mucci and Giovanna Petrucci and Ester Vitacolonna and Stefano Lattanzio and Domenico Mattoscio and Francesco Zaccardi and Rossella Liani and Natale Vazzana and Adriana Del Ponte and Elisabetta Ferrante and Filippo Martini and Carmine Cardillo and Roberta Morosetti and Massimiliano Mirabella and Giovanni Ghirlanda and Giovanni Dav{\'i} and Carlo Patrono},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2012},
  volume={10 7},
  pages={1220-30}
}
BACKGROUND Interindividual variability in response to aspirin has been popularized as 'resistance'. We hypothesized that faster recovery of platelet cyclooxygenase-1 activity may explain incomplete thromboxane (TX) inhibition during the 24-h dosing interval. OBJECTIVE To characterize the kinetics and determinants of platelet cyclooxygenase-1 recovery in… CONTINUE READING