The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen.

@article{Kuo2012TheRL,
  title={The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen.},
  author={C Kuo and Po-Ku Chen and Bi-Ing Chang and Meng-Chen Sung and Chung-Sheng Shi and J Lee and Chuan-Fa Chang and G Shi and H. -C. Wu},
  journal={Blood},
  year={2012},
  volume={119 5},
  pages={1302-13}
}
Lewis Y Ag (LeY) is a cell-surface tetrasaccharide that participates in angiogenesis. Recently, we demonstrated that LeY is a specific ligand of the recombinant lectin-like domain of thrombomodulin (TM). However, the biologic function of interaction between LeY and TM in endothelial cells has never been investigated. Therefore, the role of LeY in tube formation and the role of the recombinant lectin-like domain of TM-TM domain 1 (rTMD1)-in antiangiogenesis were investigated. The recombinant TM… CONTINUE READING
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