The recognition of adsorbed and denatured proteins of different topographies by beta2 integrins and effects on leukocyte adhesion and activation.

@article{Brevig2005TheRO,
  title={The recognition of adsorbed and denatured proteins of different topographies by beta2 integrins and effects on leukocyte adhesion and activation.},
  author={Thomas Brevig and Bj\orn Holst and Zahida Ademovic and No{\'e}mi Rozlosnik and Jette H R\ohrmann and Niels B. Larsen and Ole C Hansen and Peter Kingshott},
  journal={Biomaterials},
  year={2005},
  volume={26 16},
  pages={3039-53}
}
Leukocyte beta2 integrins Mac-1 and p150,95 are promiscuous cell-surface receptors that recognise and mediate cell adhesion to a variety of adsorbed and denatured proteins. We used albumin as a model protein to study whether leukocyte adhesion and activation depended on the nm-scale topography of a protein adlayer. Albumin adsorbed from the native conformation gave rise to different adlayer topographies and different amounts of adsorbed protein on hydrophobic and relatively hydrophilic… CONTINUE READING