The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum of the dy mouse

@article{Sakuma2002TheRC,
  title={The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum of the dy mouse},
  author={Kunihiro Sakuma and Kimi Watanabe and Tsuyoshi Totsuka and Mamoru Sano and Hiroshi Nakano and Ryuta Nakao and Jun-ji Nishikawa and Yoshihide Sorimachi and K. K. Yoshimoto and Masahiro Yasuhara},
  journal={Acta Neuropathologica},
  year={2002},
  volume={104},
  pages={482-492}
}
Laminin α2 (merosin)-deficient congenital muscular dystrophy (CMD) patients show progressive muscle fiber necrosis and ineffective muscle regeneration, probably due to a lower formation of multinucleated myotubes due to an adhesion defect of myoblasts to each other. Some recent studies found that CMD patients have a white matter disorder and cerebellum atrophy. In the spinal cord of dy mice, a model of CMD, inducible nitric oxide synthase (iNOS) was markedly expressed. Using Western blotting… CONTINUE READING