The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

@article{Zhou2012TheRO,
  title={The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.},
  author={Li Li Zhou and Wei Cao and Chao Xie and Jianwei Tian and Zhanmei Zhou and Qiugen Zhou and Ping Zhu and Aiqing Li and Youhua Liu and Toshio Miyata and Fan-fan Hou and Jing Nie},
  journal={Kidney international},
  year={2012},
  volume={82 7},
  pages={759-70}
}
The accumulation of plasma advanced oxidation protein products (AOPPs) is prevalent in chronic kidney disease. We previously showed that accumulation of AOPPs resulted in podocyte apoptosis and their deletion by a cascade of signaling events coupled with intracellular oxidative stress. The transmembrane receptor that specifically transmits the AOPPs' signals to elicit cellular activity, however, remains unknown. Using co-immunoprecipitation and immunofluorescence, we found that AOPPs… CONTINUE READING
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