The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord

@article{Schmidt2007TheRG,
  title={The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord},
  author={Hannes Schmidt and Agne Stonkute and Ren{\'e} J{\"u}ttner and Susanne Sch{\"a}ffer and Jens Buttgereit and Robert Feil and Franz Hofmann and Fritz G Rathjen},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={179},
  pages={331 - 340}
}
Sensory axonal projections into the spinal cord display a highly stereotyped pattern of T- or Y-shaped axon bifurcation at the dorsal root entry zone (DREZ). Here, we provide evidence that embryonic mice with an inactive receptor guanylyl cyclase Npr2 or deficient for cyclic guanosine monophosphate-dependent protein kinase I (cGKI) lack the bifurcation of sensory axons at the DREZ, i.e., the ingrowing axon either turns rostrally or caudally. This bifurcation error is maintained to mature stages… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

cation and development of female reproductive organs

  • T. Tsuji, T. Kunieda
  • Proc. Natl. Acad. Sci
  • 2005
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…