The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha.

@article{Lohwasser2006TheRF,
  title={The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha.},
  author={Christina Lohwasser and Daniel Neureiter and Bernd Weigle and Thomas W. Kirchner and Detlef B Schuppan},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 2},
  pages={291-9}
}
Advanced glycation end products (AGEs) form non-enzymatically from reactions of proteins with reducing sugars. In the skin, AGEs were reported to accumulate in dermal elastin and collagens and to interact nonspecifically with the cell membrane of dermal fibroblasts. Therefore, AGEs may influence the process of skin aging. We investigated the presence of the AGE receptor RAGE in skin and the influence of AGEs on receptor expression and the formation of extracellular matrix (ECM). Sections of sun… CONTINUE READING
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