The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.

@article{Zoelen2009TheRF,
  title={The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.},
  author={Marieke A. D. van Zoelen and Marcel Schouten and Alex F. de Vos and Sandrine Florquin and Joost C M Meijers and Peter P Nawroth and Angelika Bierhaus and Tom van der Poll},
  journal={Journal of immunology},
  year={2009},
  volume={182 7},
  pages={4349-56}
}
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia. The receptor for advanced glycation end products (RAGE) is a multiligand receptor that is expressed ubiquitously in the lungs. Engagement of RAGE leads to activation of multiple intracellular signaling pathways, including NF-kappaB and subsequent transcription of several… CONTINUE READING