The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.

@article{Mueller2013TheRF,
  title={The receptor for activated complement factor 5 (C5aR) conveys myocardial ischemic damage by mediating neutrophil transmigration.},
  author={Martin R. Mueller and Christine Herzog and Jan Larmann and Martina Schmitz and Denise Hilfiker-Kleiner and J. Engelbert Gessner and Gregor Theilmeier},
  journal={Immunobiology},
  year={2013},
  volume={218 9},
  pages={1131-8}
}
Tissue loss after myocardial ischemia with reperfusion (MI/R) is in part conveyed by neutrophil recruitment to post-ischemic myocardium. Strategies to prevent reperfusion injury would help to limit myocardial damage. The receptor for activated complement factor 5 (C5aR) plays a prominent role in inflammation. We examine the effects of C5aR-deficiency on reperfusion injury after MI/R. C5aR(-/-)-mice and their C57BL/6- (WT) littermates underwent transient myocardial ischemia followed by different… CONTINUE READING