The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.

@article{Klein1997TheRB,
  title={The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling.},
  author={Barbara K. Klein and Yanan Feng and C A McWherter and William F. Hood and K Paik and J P Mckearn},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 36},
  pages={22630-41}
}
Interleukin-3 (IL-3) is a member of the cytokine superfamily that promotes multi-potential hematopoietic cell growth by interacting with a cell surface receptor composed of alpha and beta chains. The newly available three-dimensional structure of a variant of human (h) IL-3 allowed us to evaluate new and existing mutagenesis data and to rationally interpret the structure-function relationship of hIL-3 on a structural basis. The amino acid residues that were identified to be important for hIL-3… CONTINUE READING
10 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

A System for X-ray Crystallography and NMR

  • A. T. Brunger
  • X-PLOR Version
  • 1992

Proteins Struct

  • A. Nicholls, K. Sharp, B. Honig
  • Funct . Genet
  • 1991

Similar Papers

Loading similar papers…