The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells.

@article{Nishikawa2004TheRA,
  title={The receptor and transporter for internalization of Clostridium botulinum type C progenitor toxin into HT-29 cells.},
  author={Atsushi Nishikawa and Nobuo Uotsu and Hideyuki Arimitsu and Jae-Chul Lee and Yutaka Miura and Yukako Fujinaga and Hiroshi Nakada and Toshihiro Watanabe and Tohru Ohyama and Yoshiyuki Sakano and Keiji Oguma},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={319 2},
  pages={
          327-33
        }
}
Orally ingested botulinum toxin enters the circulatory system and eventually reaches the peripheral nerves, where it elicits a response of neurological dysfunction. In this study, we report the important findings concerning the mechanism of Clostridium botulinum type C progenitor toxin (C16S) endocytic mechanism. C16S toxin bound to high molecular weight proteins on the surface of human colon carcinoma HT-29 cells and was internalized, but not if the cells were pretreated with neuraminidase… CONTINUE READING
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