The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.

@article{Alemi2013TheRT,
  title={The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.},
  author={Farzad Alemi and Daniel P Poole and Jonathan Orsi Chiu and Kristina Schoonjans and Fiore Cattaruzza and John R. Grider and Nigel W Bunnett and Carlos U. Corvera},
  journal={Gastroenterology},
  year={2013},
  volume={144 1},
  pages={
          145-54
        }
}
BACKGROUND & AIMS Abnormal delivery of bile acids (BAs) to the colon as a result of disease or therapy causes constipation or diarrhea by unknown mechanisms. The G protein-coupled BA receptor TGR5 (or GPBAR1) is expressed by enteric neurons and endocrine cells, which regulate motility and secretion. METHODS We analyzed gastrointestinal and colon transit, as well as defecation frequency and water content, in wild-type, knockout, and transgenic mice (trg5-wt, tgr5-ko, and tgr5-tg, respectively… CONTINUE READING
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