The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control.

@article{Cipollone2003TheRR,
  title={The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control.},
  author={Francesco Cipollone and Annalisa Iezzi and Maria Fazia and Mirco Zucchelli and Barbara Pini and Chiara Cuccurullo and Domenico De Cesare and Giovanni De Blasis and Raffaella Muraro and Roberto Bei and Francesco Chiarelli and Ann Marie Schmidt and Franco Cuccurullo and Andrea Mezzetti},
  journal={Circulation},
  year={2003},
  volume={108 9},
  pages={
          1070-7
        }
}
BACKGROUND RAGE (receptor for advanced glycation end products [AGEs]) plays a role in diabetic atherosclerosis. Recently, we have demonstrated enhanced expression of cyclooxygenase-2 and PGE synthase-1 (COX-2/mPGES-1) in human symptomatic plaques, and provided evidence that it is associated with metalloproteinase (MMP)-induced plaque rupture. However, the specific transmembrane signaling pathway(s) influencing plaque COX-2/mPGES-1 expression is unknown. The aim of this study was to characterize… CONTINUE READING

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