The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer

@inproceedings{Vedeld2014TheRS,
  title={The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer},
  author={Hege Marie Vedeld and Rolf I. Skotheim and Ragnhild A. Lothe and Guro E Lind},
  booktitle={Epigenetics},
  year={2014}
}
Recently, Dclk1 expression was identified to be an intestinal cancer stem cell specific biomarker in mouse models, implicating a potential role for targeting the DCLK1-postive cancer cells as a treatment for colorectal cancer. Using quantitative methylation specific PCR (qMSP) we here demonstrated that the DCLK1 promoter is hypermethylated in the vast majority of colorectal cancers (134/164; 82%), with no methylation in the normal mucosa samples (0/106). We further showed by Affymetrix exon… CONTINUE READING
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