The recent origins of spliceosomal introns revisited.

@article{Logsdon1998TheRO,
  title={The recent origins of spliceosomal introns revisited.},
  author={John M. Logsdon},
  journal={Current opinion in genetics & development},
  year={1998},
  volume={8 6},
  pages={637-48}
}
Does the intron/exon structure of eukaryotic genes belie their ancient assembly by exon-shuffling or have introns been inserted into preformed genes during eukaryotic evolution? These are the central questions in the ongoing 'introns-early' versus 'introns-late' controversy. The phylogenetic distribution of spliceosomal introns continues to strongly favor the intronslate theory. The introns-early theory, however, has claimed support from intron phase and protein structure correlations. 

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