The recent origins of introns.

@article{Palmer1991TheRO,
  title={The recent origins of introns.},
  author={Jeffrey D. Palmer and John M. Logsdon},
  journal={Current opinion in genetics & development},
  year={1991},
  volume={1 4},
  pages={470-7}
}
Accumulating evidence that introns are highly restricted in their phylogenetic distribution strongly supports the view that introns were inserted late in eukaryotic evolution into preformed genes and, hence, that exon-shuffling played no role in the assembly of primordial genes. Potential mechanisms of intron insertion and the possible evolution of nuclear introns and their splicing machinery from self-splicing group II introns are also discussed. 

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Current opinion in genetics & development • 1994
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