The rebel angel: mutant p53 as the driving oncogene in breast cancer

@inproceedings{Walerych2012TheRA,
  title={The rebel angel: mutant p53 as the driving oncogene in breast cancer},
  author={Dawid Walerych and Marco Napoli and Licio Collavin and Giannino Del Sal},
  booktitle={Carcinogenesis},
  year={2012}
}
Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400 000 deaths yearly worldwide. Like other tumors, it is a disease with a complex, heterogeneous genetic and biochemical background. No single genomic or metabolic condition can be regarded as decisive for its formation and progression. However, a few key players can be pointed out and among them is the TP53 tumor suppressor gene, commonly mutated in breast cancer. In particular, TP53 mutations are exceptionally… CONTINUE READING