The real mechanism of VPA-induced hyperammonemia remains unknown.

  title={The real mechanism of VPA-induced hyperammonemia remains unknown.},
  author={Chung-Chieh Hung and Tin-May Li and I L Wei and Chih-Chia Huang},
  journal={General hospital psychiatry},
  volume={33 1},
Valproic acid (VPA) is a well-tolerated and effective agent for the treatment of epilepsy, bipolar disorder, and schizoaffective disorder. Several case reports have indicated that VPA may induce serious symptomatic hyperammonemia. Based on analysis of susceptible patients, several possible mechanisms and risk factors have been proposed to identify the patients at risk. Nevertheless, we report the case of a schizoaffective patient who developed severe hyperammonemia occurring after brief… CONTINUE READING