The reactions of glutaraldehyde with nucleic acids


The kinetics of the reactions between glutaraldehyde, RNA and DNA have been investigated. At temperatures up to 64°C no reaction occurred between native DNA and glutaraldehyde. At temperatures above 75°C the reaction followed pseudofirst order kinetics, proceeding more quickly at higher temperatures. Reactions between RNA and glutaraldehyde were similar, except that they began above 45°C. These findings were corroborated by thermal transition profiles. There was little evidence for the formation of cross-links between nucleic acid molecules even at elevated temperatures.

DOI: 10.1007/BF01003595

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@article{Hopwood1975TheRO, title={The reactions of glutaraldehyde with nucleic acids}, author={David Hopwood}, journal={The Histochemical Journal}, year={1975}, volume={7}, pages={267-276} }