The reaction of the mutagen 1,1'-hexamethylene-bis-[(5-p-chlorophenyl)-biguanide] with guanosine and cysteine.

Abstract

The mutagen 1,1'-hexamethylene-bis[(5-p-chlorophenyl)-biguanide] reacts at 37 degrees C with guanosine and guanine to yield xanthosine or xanthine and oxidizes cysteine to cystine. After treatment of a guanosine-labelled DNA sample from Escherichia coli with the mutagen xanthine could be detected as a reaction product. At a slow rate the mutagen is… (More)

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