The reaction of superoxide with reduced glutathione.

  title={The reaction of superoxide with reduced glutathione.},
  author={Christine C Winterbourn and Diana Metodiewa},
  journal={Archives of biochemistry and biophysics},
  volume={314 2},
Superoxide, generated by a xanthine oxidase/hypoxanthine system, reacts with reduced glutathione (GSH) to cause an increase in oxygen consumption and oxidized glutathione (GSSG) formation, both of which are fully inhibited by superoxide dismutase. In this study we have shown that little, if any, of the additional oxygen consumed is converted to hydrogen peroxide. We have confirmed that approximately 90% of the GSH is oxidized to GSSG, the remainder being converted to the sulfonic acid… CONTINUE READING
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