The results of investigation of the influence of Staphylococcus peptidoglycan on supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei, adrenal and thyroid glands of CBA mice was studied. Alterations in the SON and PVN secretory cells were found. The percentage of neurocytes that actively synthesize and secrete the Gomori [correction of Homory]-positive substance increased. Biosynthetic functions and secretion of the hormone was enhanced. In adrenal glands, alterations were found only in the bundled zone.