The reaction of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) with the angiotensin converting enzyme inhibitor, captopril--mechanism of transnitrosation.

@article{Aquart2005TheRO,
  title={The reaction of S-nitroso-N-acetyl-D,L-penicillamine (SNAP) with the angiotensin converting enzyme inhibitor, captopril--mechanism of transnitrosation.},
  author={Danielle V Aquart and Tara P Dasgupta},
  journal={Organic & biomolecular chemistry},
  year={2005},
  volume={3 9},
  pages={1640-6}
}
Kinetic studies involving the use of both stopped-flow and diode array spectrophotometers, show that the reaction between SNAP and captopril in the presence of the metal ion sequestering agent, EDTA, occurs in two well-defined stages. The first stage is a fast reaction while the second stage is slow. The first stage has been postulated to be… CONTINUE READING