The reaction norm in gene × environment interaction

  title={The reaction norm in gene × environment interaction},
  author={Stephen B. Manuck},
  journal={Molecular Psychiatry},
Such alterations could manifest in abnormal brain development and ultimately result in psychopathology. The sex-specific nature of our correlation concurs with a previous study showing that hypomethylation at IGF2 after prenatal exposure to famine occurs specifically in males. Evidence suggests that IGF2 expression in the brain is responsive to sex hormones, which are known to alter DNA methylation at specific loci in the genome, controlling gene expression in a sex-specific manner. Future… CONTINUE READING


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