The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis.

@article{Brightling2005TheRO,
  title={The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis.},
  author={Christopher Brightling and Peter Bradding},
  journal={Current allergy and asthma reports},
  year={2005},
  volume={5 2},
  pages={130-5}
}
Asthma is characterized by variable airflow obstruction, airway hyperresponsiveness, and airway inflammation. Mast cells have long been thought to play a central role in asthma through their ability to release proinflammatory mediators, but this role has been questioned by the lack of efficacy of antihistamines and so-called mast cell-stabilizing drugs. Recent comparisons between the immunopathology of asthma and eosinophilic bronchitis have led to the re-emergence of the mast cell as a pivotal… CONTINUE READING
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