The rationale for targeting the LOX family in cancer

@article{Barker2012TheRF,
  title={The rationale for targeting the LOX family in cancer},
  author={Holly E. Barker and Thomas R Cox and Janine T Erler},
  journal={Nature Reviews Cancer},
  year={2012},
  volume={12},
  pages={540-552}
}
The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 138 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 201 references

The premetastatic niche : is metastasis random ?

  • B. Fogelgren
  • BoneKEy Rep
  • 2012

Down-regulation of lysyl oxidase-like 2 (LOXL2) is associated with disease progression in lung adenocarcinomas

  • P Zhan
  • Med. Oncol
  • 2011

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

  • Wong, C C.
  • Proc. Natl Acad. Sci. USA 108,
  • 2011

Similar Papers

Loading similar papers…