The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.

@article{Holsboer1999TheRF,
  title={The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.},
  author={Florian Holsboer},
  journal={Journal of psychiatric research},
  year={1999},
  volume={33 3},
  pages={181-214}
}
Neuroendocrine studies strongly suggest that dysregulation of the hypothalamic pituitary-adrenocortical (HPA) system plays a causal role in the development and course of depression. Whereas the initial mechanism resulting in HPA hyperdrive remains to be elucidated, evidence has emerged that corticosteroid receptor function is impaired in many patients with depression and in many healthy individuals at increased genetic risk for an depressive disorder. Assuming such impaired receptor function… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
175 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 175 extracted citations

Similar Papers

Loading similar papers…