The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option.

@article{Fassi2006TheRF,
  title={The rationale for B lymphocyte depletion in Graves' disease. Monoclonal anti-CD20 antibody therapy as a novel treatment option.},
  author={Daniel El Fassi and Claus Henrik Nielsen and Hans Carl Hasselbalch and Laszlo Heged{\"u}s},
  journal={European journal of endocrinology},
  year={2006},
  volume={154 5},
  pages={623-32}
}
We have reviewed the immunology of thyroid autoimmunity with special reference to the importance of B lymphocytes (B cells) in thyroidal and extrathyroidal Graves' disease (GD), thus providing a framework for the hypothesis that B cell depletion may be beneficial in GD. Additionally, after reviewing the efficacy and safety in other autoimmune diseases, we propose that treatment with the B cell-depleting agent Rituximab may become a clinically relevant treatment option in selected cases of GD… CONTINUE READING