The rational use of diuretics in the treatment of arterial hypertension.

  title={The rational use of diuretics in the treatment of arterial hypertension.},
  author={William J. Mroczek},
  volume={27 6},
The development of modern pharmacologic diuretic agents has revolutionized the therapy of arterial hypertension. The diuretics currently available are easily administered orally, are effective in the presence of alkalosis or acidosis, are non-toxic and have a low incidence of side effects which are readily circumvented or treated. Loop diuretics such as furosemide have the capacity to be effective in patients with diminished renal function or clinical situations that have a powerful stimulus to… 


The Value of Aggressive Therapy in the Hypertensive Patient with Azotemia
By giving diazoxide intravenously and furosemide orally the diastolic blood pressure was kept under 110 mm Hg and the urinary output over 1 L/day for a 2-week period in 25 hypertensive patients with azotemia, there was a 19% average increase in BUN and 17%Average increase in serum creatinine values.
Clinical Evaluation of Diazoxide: A New Treatment for Acute Hypertension
Repeated doses of diazoxide in both nonpregnant patients with acute hypertension and pregnant patients with toxemia adequately controlled the arterial pressure and were not associatetd with the development of drug resistance.
The syndrome of essential hypertension and suppressed plasma renin activity. Normalization of blood pressure with spironolactone.
The concept that the syndrome of essential hypertension with suppressed renin activity is related to mineralocorticoid secretion is supported.
II. HEMODYNAMIC ASPECTS OF HYPERTENSION: Influence of Extracellular Fluid Volume on Response to Antihypertensive Drugs
Changes in the extracellular fluid volume may not only account for the variability in drug response but may also contribute to the development of drug resistance.
Canrenoate in normal man
The only advantage of canrenoate over spironolactone appeared to be the parenteral administration, and was thought to be secondary to volume depletion due to a diuretic action.
Dependence of arterial pressure on intravascular volume in treated hypertensive patients.
Although adrenergic blocking drugs interfere with cardiovascular adjustments to intravascular volume expansion, reasons for this quantitative relation between pressure and plasma volume did not emerge, this study emphasizes the importance of precise volume control in maintaining blood-pressure reductions during treatment.
Relation of Extracellular Fluid Volume to Arterial Pressure during Drug‐Induced Saluresis
The fact that a decreased pressor response to norepinephrine following furosemide was associated with a decrease in extracellular fluid and the fact that expansion of extrace Cellular fluid with glucose restored the pressor responded to normal further document the importance of the extrace cellular fluid in the regulation of arterial pressure.