The rational parameterization theorem for multisite post-translational modification systems.

@article{Thomson2009TheRP,
  title={The rational parameterization theorem for multisite post-translational modification systems.},
  author={Matthew W Thomson and Jeremy Gunawardena},
  journal={Journal of theoretical biology},
  year={2009},
  volume={261 4},
  pages={626-36}
}
Post-translational modification of proteins plays a central role in cellular regulation but its study has been hampered by the exponential increase in substrate modification forms ("modforms") with increasing numbers of sites. We consider here biochemical networks arising from post-translational modification under mass-action kinetics, allowing for multiple substrates, having different types of modification (phosphorylation, methylation, acetylation, etc.) on multiple sites, acted upon by… CONTINUE READING

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