The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy.

@article{Torres2008TheRO,
  title={The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy.},
  author={Diletta Domenica Torres and Michele Rossini and Carlo Manno and Francesco U. S. Mattace-Raso and Christian D'Altri and Elena Ranieri and Paola Pontrelli and Giuseppe Grandaliano and Loreto Gesualdo and Francesco Paolo Schena},
  journal={Kidney international},
  year={2008},
  volume={73 3},
  pages={327-33}
}
The production of cytokines by resident and non-resident renal cells during immunoglobulin A nephropathy (IgAN) plays a key role in the progression of renal damage. The aim of this study was to determine if measurements of urinary epidermal growth factor (EGF) and monocyte chemotactic peptide-1 (MCP-1), at the time of renal biopsy, were a predictor of end-stage renal disease (ESRD) in a cohort of 132 patients with biopsy-proven IgAN. Outcome measures were a doubling of the baseline serum… CONTINUE READING
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